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Ranked #1 CRO1

Antibody Discovery and Characterization

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ENGINEERED for the Scientific Race

Excellence in antibody discovery and mAb characterization

Overview

Innovative platforms deliver high-affinity antibodies 

IPA provides services to characterize valuable monoclonal antibodies. Specificity testing in various assays can be complemented with internalization, affinity ranking of antibody panels, and epitope binning, using BLI-based platforms. This also includes highly purified, well-characterized, low endotoxin, or labeled antibodies for various applications.

Services

Antibody Discovery

Data-driven and proprietary Function-First antibody discovery technologies and platforms feed B cell Select®, phage display, and hybridoma generation, using semi-solid media and clone picking, to deliver high affinity antibodies for your therapeutic pipeline.

B cell Select

Proprietary Function-First B cell Select platform allows for the interrogation of a great diversity of an animal’s antibody repertoire…

Rabbits & Chickens

Allows for screening of the immune repertoire of rabbits and chickens and select the desired antibody directly from the B cells using our B cell Select or phage display…

Single-Step Hybridoma

Use of proprietary, semi-solid media to grow mouse and rat hybridomas, for the support and picking of single cell colonies immediately after the fusion…

DeepDisplay™

A combination of custom IPA phage display antibody selection and transgenic animals…


Phage Display

Based on building custom immune libraries from multiple species, including transgenic animals, or the selection of antigen-specific recombinant antibody fragments from IPA human or llama phage libraries…

CAR Development

Supports your chimeric antigen receptor (CAR) development by providing adaptable antibody discovery approaches and custom work plans designed to meet your criteria…

Antibody Characterization

Unrivaled experience in sequencing and custom assay development.

Antibody Sequencing

Protect valuable monoclonal antibodies with ImmunoProtect™…

Assay Development

Full, custom assay development and in-house catalog services…

Antibody Discovery

Decades of experience

B cell Select

From decades of experience, the B cell Select platform allows for the interrogation of a great diversity of an animal’s antibody repertoire. Antibodies can be developed from any species (including human) or tissue, can explore the entire antibody repertoire, and identify antibodies for any possibilities in an animal’s immune repertoire including any protein class, complex therapeutic targets, post-translational modifications, and small molecules. The B cell Select technology enables the interrogation of 10 million immune cells to generate native, monoclonal antibodies from immunized animals that specifically target an antigen and allow for the rapid selection of top candidates, increasing the success rate of an antibody discovery program. The platform also harnesses the power of the immune system to generate natural pairing of the antibodies produced by selected B cells. 

IPA B cell Select

Great diversity of the animal’s antibody repertoire

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Diverse immune repertoires

Rabbits & Chickens

IPA offers rabbit and chicken monoclonal antibody development. Proprietary technology from IPA allows for the screening of the immune repertoire of the animal, creating the power to select the desired antibody directly from the B cells using our B cell Select or phage display, antibody discovery platforms.

Semi-solid media and clone picking

Single-Step Hybridoma

IPA uses proprietary, semi-solid media to grow mouse and rat hybridomas, post-fusion. This special media allows for the support and picking of single cell colonies immediately after the fusion and (hybridomas are essentially monoclonal from the start). No serial dilution (limiting dilution) cloning is required and all hybridomas that grow from the fusion can be tested for specific antibodies, within two weeks post-fusion. The quick detection of target-specific clones allows for immediate subcloning and cryopreservation of valuable cultures.

IPA Semi-Solid Media and Clone Picking

Grow rat and mouse hybridomas post-fusion

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Transgenic and phage display

DeepDisplay™

DeepDisplay technology utilizing a combination of any transgenic animal platform and custom IPA phage display antibody selection.

Any Ig format

Phage Display

Our phage display approach is based on building custom immune libraries from multiple species, including transgenic animals, or the selection of antigen-specific recombinant antibody fragments from our proprietary, pre-made human or llama phage libraries. Our libraries have been made from human patient and naïve (scFv) repertoires, as well as from naïve llama (VHH) repertoires. DeepDisplay custom immune libraries are prepared from blood, spleen, lymph nodes, and bone marrow of immunized animals or humans and capture the entire immune repertoire for panning, rescue, and identification of unique antibodies with pre-specified characteristics.

This advanced technology allows us to express antibody fragments in bacteria or rapidly reformat into any given Ig format, such as full-size IgG of various isotypes, bispecifics, Fc mutants to modify effector functions, or chimeras with Fc regions from different species.

IPA Phage Display

Custom immune libraries from multiple species

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Diverse format options for CAR-T

CAR Development

IPA supports chimeric antigen receptor (CAR) development by providing adaptable antibody discovery approaches and custom work plans designed to meet your requirements. Our diverse antibody discovery platforms, generate antibodies in different formats for CAR-T, while our precise high-throughput screening and characterization allows the inclusion of functional data early in the screening funnel. Multiple discovery methods yield broad spectrums of diverse antibodies, for further optimization with our platforms. Our human scFv library offers especially accelerates discovery timelines to complete your project with quality and efficiency.

IPA CAR Development

High-throughput screening and characterization enable early functional insights

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Antibody Characterization

Hybridoma cell line experts

Antibody Sequencing

It is critical to understand how to manage hybridoma cell lines and their potential to become unstable over time, and stop secreting antibody. With ImmunoProtect™, the DNA sequences of desirable antibodies are identified and subsequently used to produce your antibody recombinantly.

IPA Antibody Sequencing

Desirable antibodies identified and produced recombinantly

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Full customization

Assay Development

Custom assay development services fully tailored to your needs. IPA also provides assays developed in-house, available in our Products Catalog (e.g., Arthritis antibody mix (CAIA), PAD enzyme assay).

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Eligible French companies involved with us in research and development may receive a tax credit. Learn More.

1. ROOTS 2022: Antibody Discovery Services and Platforms Market (4th Edition), 2021-2035; p.118

In silico, in parallel, in an instant

LENSai Integrated Intelligence Technology

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Your ultimate source for protein production

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Extensive catalog of antibodies and recombinant proteins, including organoid growth factors: IPA is exclusive producer of WNT Surrogate-Fc fusion protein that is cited in multiple peer review journals.

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Custom Programs


IPA custom rPEx® production: >8,000 batches of antigens, antibodies, bi- and multi-specific antibodies with >95% purity* — renowned for its flexibility, reliability and efficiency. Discover our excellence. Programs shipped in 8 weeks / 4 weeks for repeat batch production.

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*Historical consolidated average

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