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Protein Manufacturing
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Ranked #1 CRO1

Optimization and Engineering

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ENGINEERED for the Scientific Race

Enhanced clinical profile and lead candidate performance

Overview

Track record of success in optimizing lead antibody candidates for clinical readiness.

Optimization of therapeutic antibody lead candidates is often required to improve and enhance their clinical profiles. With over a decade of experience affinity maturation programs completed and >96% success rate humanizing antibodies from a variety of species, including rabbit and chicken, IPA is the clear choice.

Services

Optimization & Engineering

Antibody Humanization (LucinaTech®)

State-of-the-art in silico antibody modeling using our Artemis™ Intelligence Metadata (AIM)™…

Antibody Affinity Maturation
 

Designed to increase antibody affinities …


Antibody Chimerization

Cloning and production of any variable antibody domain…

Robust and efficient

Antibody Humanization (LucinaTech®)

Animal-derived monoclonal antibodies can elicit human anti-animal antibody responses in patients. For that reason, it is often necessary to replace the animal-derived regions of the molecule with the corresponding human amino acid residues. You can depend on the robust and efficient antibody humanization services at IPA to retain affinity and specificity levels, consistently. Our approach is rooted in state-of-the-art in silico antibody modeling using our Artemis™ Intelligence Metadata (AIM)™ capabilities to identify essential framework and CDR residues for grafting onto a human antibody framework.

IPA Antibody Humanization

In silico modeling to identify essential framework and CDR residues for grafting on human framework

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Increase antibody affinity

Antibody Affinity Maturation

Antibody affinity is vital in therapeutic and diagnostic applications. The antibody affinity maturation service at IPA is designed to improve antibody affinities multiples times over. We apply different strategies to increase the affinity of your antibody, including gene shuffling and random mutagenesis.

Cloning and production

Antibody Chimerization

Cloning and production of any variable antibody domain into any immunoglobulin context required, such as full-size mouse, rabbit, chicken, or human format, chimeras with any Fc region of choice, including effector mutants or Fc fusions.

IPA Antibody Chimerization

Any variable antibody domain into any immunoglobulin context

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Eligible French companies involved with us in research and development may receive a tax credit. Learn More.

1. ROOTS 2022: Antibody Discovery Services and Platforms Market (4th Edition), 2021-2035; p.118

In silico, in parallel, in an instant

LENSai Integrated Intelligence Technology

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Your ultimate source for protein production

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Extensive catalog of antibodies and recombinant proteins, including organoid growth factors: IPA is exclusive producer of WNT Surrogate-Fc fusion protein that is cited in multiple peer review journals.

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Custom Programs


IPA custom rPEx® production: >8,000 batches of antigens, antibodies, bi- and multi-specific antibodies with >95% purity* — renowned for its flexibility, reliability and efficiency. Discover our excellence. Programs shipped in 8 weeks / 4 weeks for repeat batch production.

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*Historical consolidated average

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