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Ranked #1 CRO1

Developability Profiling

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ENGINEERED for the Scientific Race

High-throughput assessment

Overview

Efficient identification of candidates for clinical success 

Successful translation of a therapeutic antibody candidate to the clinic depends on its physicochemical properties. Antibody degradation or instability for example, can have a great impact on its biological function. IPA streamlines in silico and in vitro processes with high-throughput workflows for developability profiling, by assessing critical antibody quality attributes.

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Developability Profiling

IPA’s workflow is based on throughput and parallel efforts to monitor potential liabilities in an early stage. Based on the developability assessment, lead antibodies can be subjected to sequence optimization to enhance success rate for clinical translation.

In Silico Analyses

In silico analyses include identification of potential chemical liabilities and aggregation-prone surface areas…

In Vitro Analyses

In vitro analytical tools study various critical quality attributes such as production yield, target- and/or poly-reactivity, colloidal stability, melting temperature, self- and/or cross-interaction, solubility, and fragmentation…

 

In silico

In Silico Analysis

IPA’s in silico developability profiling toolset includes sequence analysis, Fv model-based structure analysis, and Fv model-based surface analysis for antibody lead candidates to identify e.g. chemical liability motifs, aggregation prone regions, and charge properties. These in silico engineering approaches facilitate focused antibody de-risking, if required, to improve the mAb developability profile.

In vitro

In Vitro Analysis

In vitro analytical tools allow for the study of various critical quality attributes like production yield, target- and/or poly-reactivity, colloidal stability, melting temperature, self- and/or cross-interaction, solubility, and fragmentation.

IPA is equipped with a state-of-the-art bio-inert HPLC enabling analytical determination of mAb biochemical and biophysical properties such as aggregation levels (SEC-HPLC), colloidal stability (SMAC-HPLC), cross interaction (CIC-HPLC), Asn deamidation and isomerization (CIEX-HPLC), and Met/Trp oxidation (HIC-HPLC).

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Eligible French companies involved with us in research and development may receive a tax credit. Learn More.

1. ROOTS 2022: Antibody Discovery Services and Platforms Market (4th Edition), 2021-2035; p.118

In silico, in parallel, in an instant

LENSai Integrated Intelligence Technology

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Your ultimate source for protein production

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Extensive catalog of antibodies and recombinant proteins, including organoid growth factors: IPA is exclusive producer of WNT Surrogate-Fc fusion protein that is cited in multiple peer review journals.

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Custom Programs


IPA custom rPEx® production: >8,000 batches of antigens, antibodies, bi- and multi-specific antibodies with >95% purity* — renowned for its flexibility, reliability and efficiency. Discover our excellence. Programs shipped in 8 weeks / 4 weeks for repeat batch production.

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*Historical consolidated average

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