Mammalian protein expression and purification services tailored to your needs.
IPA offers mammalian protein expression and purification services as stand-alone or in combination with a previous or ongoing antibody discovery project. We work with you to produce the antibodies you need to achieve your goals. Our expression and production workflow are designed to deliver recombinant proteins and antibodies for research and pre-clinical applications. Antibodies can be manufactured from a transient expression system, from stable cell lines, or from hybridoma culture or animal sera.
We know the importance of the target protein for a successful antibody campaign.
Platform allowing the production of all kinds of proteins, including difficult-to-express proteins, Fc-fusion proteins, and bispecific antibodies.
Transient Protein Production Platform (rPEx®)
Fully post-translationally modified mammalian proteins and recombinant antibodies produced via the rPEx® transient protein production platform. Serum-free, suspension-growing HEK and CHO cells transiently transfected with expression vectors containing the gene of interest. Several proprietary expression vectors (pUPE) are available for small-scale high-throughput production for quick candidates screening. Gram amounts of purified antibodies in any format and with low levels of endotoxin (< 1.0 EU/mg) can be produced quickly and in high quality. Any antibody variable domains can be seamlessly ligated in antibody expression vectors to generate each antibody class or type.
Broad expertise with bispecific antibody generation using discovered lead sequences for bispecific binding validation, using a knob-into-hole heterodimer platform (Abthena™), and for generation of bispecific antibodies for your research purposes (based on your bispecific antibody platform licenses). Vast experience with subcloning binders into different formats and the production of sufficient protein amounts for internal testing. We are also able to use a comparative approach and tech-transfer your bispecific technology, to benchmark against other bispecific antibody formats.
Trusted partner for the storage of cell lines, tissues, RNA, DNA, plasmid constructs, antibodies, and many other biological materials. We use an off-site storage facility to safeguard your assets.
Lead the way with IPA.
We have the longest memory
Rabbit monoclonal antibodies with B Cell Select® with Function-First from IPA are unmatched for early identification of a high affinity, highly specific antibodies.
Bispecifics & IPA
Bring us your scaffold and we can do the rest. With years of experience using a variety of bi- and multi-specific modalities, IPA has end-to-end capabilities and throughput to ensure selection and development of the most relevant therapeutic candidates.
Wet lab + in silico
LENSai in silico applications for radically informed decisions are designed to lend great cost and time efficiencies, as part of the IPA antibody discovery portfolio of service.